IRAQ: Brain Tissue on a Microchip Aids Iraqi Scientist Dr Mootaz Salman’s Search for Better Stroke Treatments

The Iraqi researcher Mootaz Salman has won the “Young Scientist Lectureship Award” for research that involved putting human brain tissue on a microchip and using innovative technology to treat neurodegenerative diseases.

Salman started his academic career at the University of Mosul, where he earned a Bachelor of Pharmacy with Honours, and is now is a senior researcher and lecturer in the department of physiology, anatomy and genetics at the University of Oxford.

He spoke to Al-Fanar Media about his work, which has taken nearly ten years of research, and the experiences that led him to his current post.

The first researcher in Britain to win the award, Salman said the support he received from universities where he had worked  in the United States and the United Kingdom had been a key factor.

“I deeply believe that the more a person works, the more fortunate he is,” Salman said.

“From the very beginning, I was aware of the challenges ahead, the double effort I had to make, as an academic from a conflict country, and the responsibility I had to convey a different image of my country and to help humanity provide solutions to brain diseases and stroke, which have risen dramatically.”

Human Brain Tissue on a Microchip

The International Society for Neurochemistry and the and Asian-Pacific Society for Neurochemistry will present Salman with the award in September in Honolulu, Hawaii.

Salman led a research team that used  a human brain “microvessel on a chip” to study what happens when drugs cross from the bloodstream into the brain.

The research was part of his ongoing work to understand the cellular physiology of the blood-brain barrier and exploit its mechanisms to improve the effectiveness of therapeutic treatments of neurological diseases such as Alzheimer’s disease, multiple sclerosis, and Parkinson’s disease.

The device the researchers designed for the study allowed them to track the movement of tiny molecular sizes across the blood-brain barrier. Their device is ideal for studies involving biotherapies, as well as being able to employ it in high-resolution imaging methods, such as transmission electron microscopy, Salman said.

Academic Journey

Before moving to the University of Oxford two years ago as an assistant professor and lecturer at Wolfson College, Salman was a postdoctoral fellow at Harvard Medical School and Boston Children’s Hospital in the United States.

Before that, he earned a master’s degree and a Ph.D. from Sheffield Hallam University, in the United Kingdom.

During his doctoral studies, he discovered a new pharmacological framework for developing drugs to treat patients with brain tumours resulting from accidents and strokes.

This research focused on water receptors in the brain. Salman described it as a turning point that helped him recognise the molecular mechanics of brain diseases and think of ways to provide therapeutic solutions rather than surgery, which has major risks and complications.

He said the research led him to discover how cells develop brain tumours and the mechanics that cause these tumours and strokes at the molecular level.

A World Health Organization report says that about 75 million people in the world suffer from strokes annually. About five million of them die and another five million suffer permanent disability.

Salman says the incidence of brain disease in the Arab world is rising because of the dietary and living patterns of the majority of the population, the intake of fats and sugars at “unreasonable” rates, the lack of physical activity, and the pressures of daily life.

Difficulty of Research in Arab Countries

After graduating from the University of Mosul, Salman worked as a teaching assistant in the university’s Faculty of Pharmacy for about two years and experienced firsthand the difficulties of research in the Arab world. He said there was no financial support for conducting research, research laboratories were limited, and the teaching and administrative burdens on professors usually led them to abandon research.

Salman said scientific research should be considered “an investment,”  not a “random academic luxury.” Such work only flourishes in a suitable environment where there is stability and financial support, he said.

He believes the political unrest Iraq has experienced in recent years has affected teaching in universities and Iraqi researchers’ chances for professional development. He described government support for Iraqi universities as “very limited” and said most research initiatives were “individual and random” and did not amount to regular institutional work.

A Call for Greater Investment in Research

Salman said Arab countries needed to increase investment in scientific research at the national level and benefit from the experience of wealthy Gulf countries that have attracted foreign and Arab professors from major European and American universities to establish research centres where young researchers can train.

He said he had tried to open communication channels between the University of Oxford and Iraqi universities to reach agreements for cooperation and scientific research, which could provide research fellowships for Iraqi researchers at British universities.

This year, the University of Mosul signed a cooperation agreement with Oxford on a project that uses remote sensing and photographic information systems to study antiquities. The work would preserve the cultural heritage of Nineveh Governorate and other Iraqi provinces, and attract Ph.D. students to training courses at British universities.

Salman said: “These efforts give me a high sense of pride and a greater incentive for hard work and research that benefits all humanity. I feel a sense of responsibility and love towards my country, my city and my mother university, which helped me and paved the way for me at the beginning of my academic journey.”

source/content: al-fanarmedia.org (headline edited)

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Mootaz Salman, an Iraqi scientist at the University of Oxford, has won the “Young Scientist Lectureship Award” for his use of innovative technology to treat neurological diseases. (Photo: Mootaz Salman).

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IRAQ

IRAQ: Chemistry Scientist and Researcher Dr.Suhad Yasin’s Work on Purifying Water Has Been a Journey of Perseverance

The Iraqi scholar Suhad Yasin has waged a long battle against financial and administrative obstacles to continue her work on purifying polluted water.

Her graduate studies started later than most and became a long journey over 13 years of dropping out and restarting, but she persevered. Two years ago, the University of Duhok awarded her a doctorate in polymer chemistry.

Now Yasin works from an independent laboratory she set up at the University of Duhok, where she and her students use cheap, available materials to treat polluted water.

Iraq, like many Arab countries,  suffers from water scarcity and stress. One study predicts  the Tigris and Euphrates rivers will dry up completely by 2040. 

Apart from the scarcity issue, some Iraqi waterways also face problems with contamination by heavy metals like aluminum, cadmium and chromium, adding urgency to research like Yasin’s.

An Interrupted Academic Journey

In an interview with Al-Fanar Media, Yasin described her career in industry and academe.

After obtaining her bachelor’s degree in chemistry at the University of Mosul in 1993, she joined a laboratory in a local pharmaceutical factory, eventually becoming production manager.

As violence increased in Mosul over the next decade, however, Yasin was forced to return to her family’s home city of Duhok in 2006. She got an administrative job at the Ministry of Industry of the Kurdistan Region of Iraq.

But she did not find administrative work satisfying, Yasin said, so she took a competitive exam to study for a master’s degree at the University of Duhok.

By then a wife and mother, Yasin faced challenges in studying at the University of Duhok, both with learning in English and in overcoming the skepticism of some academics. Her thesis supervisor questioned her ability to complete the work. “He told me, ‘I regret being involved in the supervision of your thesis. It will be difficult for you to complete your studies at your age because of your family responsibilities.’”

But Yasin said his words only increased her motivation. “I needed to prove to my supervisor and myself that I was not a problem, but an energetic researcher who had missed an opportunity,” she said.

Yasin got her master’s degree with excellence in 2009 with a thesis on removing chromium from water using modified pomegranate peel .

Starting from Scratch on a Ph.D.

She then applied to transfer from her job at the ministry to work as an assistant teacher in the chemistry department of the University of Duhok’s Faculty of Science.

She taught at the University of Duhok   for six years but was not given an opportunity to pursue a Ph.D. because the university lacked facilities and funds for research in her specialisation. Throughout this time, she continued her research on purifying polluted water.

In 2015, the university offered her an opportunity to pursue a doctorate and she took it. There was considerable opposition to her studying for a Ph.D. at the age of 50, but she managed to convince the head of the department.

Based on the advice of her master’s supervisor, who had changed his mind about her ability, she chose nanofiber technology as the subject of her doctorate. Her new supervisor initially opposed the idea, saying the university could not afford the materials required for research on this topic. But he finally relented when she persisted.

Yasin said she had nothing but the lab walls when she started her doctoral research: no equipment, devices, or “cofactors”, molecular compounds needed in certain chemical reactions. “The resources were almost zero,” she said. “I had to buy everything myself and start from scratch.” 

Lining up Support

Yasin contacted professors and scholars from various Arab countries to ask for help. By chance, she heard of a physics professor at the University of Basrah who had designed a device that would help her with her research. “I contacted the professor at the University of Basrah immediately and she agreed to help me,” Yasin said.

Yasin then had to convince her dean at the University of Duhok to manufacture a similar device so she could work. He agreed, but she still needed funding for her research.

She wrote to several international organisations asking for financial support and eventually received a three-year grant of about $207,000 from the National Academy of Sciences in the United States, in 2018. She used the money to establish an independent laboratory at the University of Duhok to conduct her research on using nanomaterials to treat water.

Yasin acknowledges that funding scientific research is a general problem in Arab countries, but she insists that scholars themselves have a duty to find funding for their research.

“We must not stand idly by. I work day and night to get new financial support,” she said. “With each refusal, I realise that I have to work more.”

source/content: al-fanarmedia.org (headline edited)

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Suhad Yasin, of the University of Duhok, overcame many obstacles during 13 years of interrupted graduate study to continue her research on purifying polluted water. (Photo courtesy of Suhad Yasin)

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IRAQ